| Identification | Back Directory | [Name]
SMYD3-IN-1 | [CAS]
2095160-79-3 | [Synonyms]
SMYD3-IN-1
SMYD-3-IN-1,SMYD3 IN 1,SMYD3IN1
1-Piperazinecarboxylic acid, 4-[[2-[4-(1-aminocyclopropyl)phenyl]-4-chloro-7-quinolinyl]carbonyl]-2-methyl-, propyl ester, (2R)- | [Molecular Formula]
C28H31ClN4O3 | [MDL Number]
MFCD32174298 | [MOL File]
2095160-79-3.mol | [Molecular Weight]
507.02 |
| Chemical Properties | Back Directory | [Boiling point ]
666.7±55.0 °C(Predicted) | [density ]
1.284±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
7.27±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
SMYD3-IN-1 (compound 29) is an irreversible and selective inhibitor of SMYD3 (SET and MYND domain containing 3), with an IC50 of 11.7 nM[1]. | [IC 50]
SMYD3: 11.7 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Huang C, et al. Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3. ACS Med Chem Lett. 2019 May 23;10(6):978-984. DOI:10.1021/acsmedchemlett.9b00170 |
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