| Identification | Back Directory | [Name]
eIF4A3 inhibitor 53a | [CAS]
2095486-67-0 | [Synonyms]
eIF4A3-IN-1
eIF4A3 inhibitor 53a
eIF4A3-IN-1 (compound 53a)
Benzonitrile, 3-[4-[[(3S)-4-(4-bromobenzoyl)-3-(4-chlorophenyl)-1-piperazinyl]carbonyl]-5-methyl-1H-pyrazol-1-yl]- | [Molecular Formula]
C29H23BrClN5O2 | [MDL Number]
MFCD32174248 | [MOL File]
2095486-67-0.mol | [Molecular Weight]
588.88 |
| Chemical Properties | Back Directory | [Boiling point ]
769.3±60.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
-1.02±0.12(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD[1]. | [References]
[1] Ito M, et al. Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors. J Med Chem. 2017 Apr 27;60(8):3335-3351. DOI:10.1021/acs.jmedchem.6b01904 |
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