| Identification | Back Directory | [Name]
RIP1 kinase inhibitor 1 | [CAS]
2095515-38-9 | [Synonyms]
RIP1 kinase inhibitor 1
RIP-1 kinase inhibitor 1,RIP1 kinase inhibitor 1
1,5-Benzoxazepine-8-carbonitrile, 3-[3-chloro-2,4,5,7-tetrahydro-7-oxo-2-(phenylmethyl)-6H-pyrazolo[3,4-c]pyridin-6-yl]-2,3,4,5-tetrahydro-5-methyl-4-oxo-, (3S)- | [Molecular Formula]
C24H20ClN5O3 | [MDL Number]
MFCD32174267 | [MOL File]
2095515-38-9.mol | [Molecular Weight]
461.9 |
| Chemical Properties | Back Directory | [Boiling point ]
798.9±60.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
-0.75±0.20(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04)[1]. | [References]
[1] Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, OrallyAvailable, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61(6):2384-2409. DOI:10.1021/acs.jmedchem.7b01647 |
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