| Identification | Back Directory | [Name]
4-Morpholineacetamide, N-[4-[[5-chloro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenyl]- | [CAS]
2095883-62-6 | [Synonyms]
DPPY
4-Morpholineacetamide, N-[4-[[5-chloro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenyl]- | [Molecular Formula]
C25H26ClN7O3 | [MOL File]
2095883-62-6.mol | [Molecular Weight]
507.97 |
| Hazard Information | Back Directory | [Uses]
DPPY (compound 6) is a potent PTK inhibitor with IC50 values of <10, <10, <10 nM for EGFR, BTK, JAK3, respectively. DPPY shows anti-proliferative activity against B-cell lymphoma cells. DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF)[1]. | [IC 50]
JAK3: <10 nM (IC50); EGFR: <10 nM (IC50); BTK: <10 nM (IC50) | [References]
[1] Zhu Y, et al. Synthesis and biological activity of thieno[3,2-d]pyrimidines as potent JAK3 inhibitors for the treatment of idiopathic pulmonary fibrosis. Bioorg Med Chem. 2020 Jan 15;28(2):115254. DOI:10.1016/j.bmc.2019.115254 |
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