| Identification | Back Directory | [Name]
PF-3893787 hydrochloride | [CAS]
2096455-90-0 | [Synonyms]
PF-3893787 hydrochloride
Adriforant hydrochloride | [Molecular Formula]
C13H25ClN6O | [MDL Number]
MFCD31630832 | [MOL File]
2096455-90-0.mol | [Molecular Weight]
316.83 |
| Hazard Information | Back Directory | [Uses]
Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor antagonist binding affinity (Ki=2.4 nM) and is also a functional (Ki=1.56 nM) antagonist. | [Biological Activity]
Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor affinity antagonist (Ki=2.4 nM) and a functional H4 receptor antagonist (Ki=1.56 nM). | [in vitro]
Adriforant is tested and observed binding K i =2.4 nM and functional K i =1.56 nM for H4R. Data from functional assays produce convergent projections of the free plasma efficacious concentration and Adriforant (Compound 13) is fast on/fast off on rhH4R. | [target]
Ki: 2.4 nM (H4R bind), 1.56 nM (H4R func) | [storage]
Store at -20°C | [References]
[1] Mowbray CE, et al. Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602. DOI:10.1016/j.bmcl.2011.07.125 |
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BOC Sciences
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MedChemExpress
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www.medchemexpress.com |
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