| Identification | Back Directory | [Name]
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-butyl-6-(4-hydroxyphenyl)- | [CAS]
2097024-37-6 | [Synonyms]
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-butyl-6-(4-hydroxyphenyl)- | [Molecular Formula]
C22H19NO3 | [MOL File]
2097024-37-6.mol | [Molecular Weight]
345.39 |
| Chemical Properties | Back Directory | [Boiling point ]
533.0±38.0 °C(Predicted) | [density ]
1.274±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.34±0.15(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
UGT1A1-IN-1 (compound 2) is a non-competitive inhibitor of UGT1A1, which can inhibit the 1-O-glucuronidation process mediated by UGT1A1 with a Ki value of 5.02 μM. UGT1A1-IN-1 (compound 2) can bind on UGT1A1 at the same ligand-binding site as bilirubin (HY-N0323). UGT1A1-IN-1 can serve as a ‘turn-on’ fluorescent probe substrate for UGT1A1[1]. | [References]
[1] Lv X, et al. A Practical and High-Affinity Fluorescent Probe for Uridine Diphosphate Glucuronosyltransferase 1A1: A Good Surrogate for Bilirubin. J Med Chem. 2017 Dec 14;60(23):9664-9675. DOI:10.1021/acs.jmedchem.7b01097 |
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