| Identification | Back Directory | [Name]
CHK1-IN-3 | [CAS]
2097252-39-4 | [Synonyms]
CHK1-IN-3
CHK1IN3,CHK1 IN 3,CHK-1-IN-3
2-Pyridinecarbonitrile, 5-[[4-(methylamino)-5-(1-methyl-1H-pyrazol-4-yl)-2-pyrimidinyl]amino]-3-[(3R)-3-piperidinyloxy]- | [Molecular Formula]
C20H23N9O | [MDL Number]
MFCD32067980 | [MOL File]
2097252-39-4.mol | [Molecular Weight]
405.46 |
| Chemical Properties | Back Directory | [Boiling point ]
737.0±70.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
8.58±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
CHK1-IN-3 is a Checkpoint Kinase 1 (CHK1) inhibitor with an IC50 of 0.4 nM[1]. | [in vivo]
CHK1-IN-3 significantly suppresses the tumor growth in Z-138 cell inoculated xenograft model as a single agent with body weight unaffected[1]. | [IC 50]
Chk1: 0.4 nM (IC50) | [References]
[1] Tong L, et al. Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies. Eur J Med Chem. 2019 Jul 1;173:44-62. DOI:10.1016/j.ejmech.2019.03.062 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|