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Isatropolone A, a natural product containing a 1,5-diketone moiety, is reisolated from Streptomyces G?66. Isatropolone A shows potent activity against Leishmania donovani with an IC50 of 0.5 μM[1]. | [IC 50]
Leishmania | [References]
[1] Xiaofeng Cai, et al. Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces G?66. Angew Chem Int Ed Engl. 2017 Apr 24;56(18):4945-4949. DOI:10.1002/anie.201701223 |
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