| Identification | Back Directory | [Name]
(R)-VU 6008667 | [CAS]
2097818-14-7 | [Synonyms]
(R)-VU 6008667
5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-, (9bR)- | [Molecular Formula]
C24H17ClF2N2O2 | [MDL Number]
MFCD32689505 | [MOL File]
2097818-14-7.mol | [Molecular Weight]
438.85 |
| Chemical Properties | Back Directory | [Boiling point ]
616.1±55.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mg/mL (227.87 mM) | [form ]
Solid | [pka]
-2.76±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(R)-VU 6008667, the less active (R)-enantiomer to VU 6008667, is devoid of M5 NAM activity (IC50>10 μM)[1]. | [storage]
Store at -20°C | [References]
[1] McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359. DOI:10.1016/j.bmcl.2017.02.020 |
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MedChemExpress
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