| Identification | Back Directory | [Name]
MLT-747 | [CAS]
2097853-86-4 | [Synonyms]
MLT-747
Urea, N-[2-chloro-7-[(1S)-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(1-pyrrolidinylcarbonyl)-3-pyridinyl]- | [Molecular Formula]
C20H21Cl2N7O3 | [MDL Number]
MFCD31813804 | [MOL File]
2097853-86-4.mol | [Molecular Weight]
478.33 |
| Hazard Information | Back Directory | [Description]
MLT-747 is a novel inhibitor of malt1 peptide cleavage, mimicing trp580 in malt1 | [Uses]
MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM[1]. | [References]
[1] Quancard J, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019 Mar;15(3):304-313. DOI:10.1038/s41589-018-0222-1 |
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