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2097887-21-1

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2097887-21-1 Structure

2097887-21-1 Structure
IdentificationBack Directory
[Name]

MM-589 TFA salt
[CAS]

2097887-21-1
[Synonyms]

MM-589 (TFA)
MM-589 TFA salt
[MDL Number]

MFCD32689433
Chemical PropertiesBack Directory
[storage temp. ]

-20°C, away from moisture
[solubility ]

DMSO : 25 mg/mL (36.40 mM; ultrasonic and warming and heat to 60°C)
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Hazard InformationBack Directory
[Biological Activity]

MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interactions. MM-MM-589 TFA binds WDR5 with an IC50 of 0.90 nM. IC50 for inhibition of MLL H3K4 methyltransferase activity is 12.7 nM.
[in vitro]

MM-589 TFA (0.01-10 μM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations.

Cell Viability Assay

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Cell Line: MV4-11 and MOLM-13 cells
Concentration: 0.01, 0.1, 1, 10 μM
Incubation Time: 4 days or 7 days
Result: Potently inhibited MV4-11 and MOLM-13 cell growth with IC 50 s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC 50 of 8.6 μM.
[target]

IC50: 0.90 nM (WDR5), 12.7 nM (HMT)

Ki: <1 nM (WDR5)

[storage]

-20°C, away from moisture