| Identification | Back Directory | [Name]
9ALPHA,11ALPHA-DIHYDROXY-15,15-DIFLUORO-16-PHENOXY-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID | [CAS]
209860-88-8 | [Synonyms]
AFP-172
209860-84-1
tafluprost acid
Tafluprost Impurity 9
TAFLUPROST (FREE ACID)
Tafluprost Impurity Tafluprost acid
7-[2-(3,3-difluoro-4-phenoxybut-1-enyl)-3,5-dihydroxycyclopentyl]hept-5-enoic acid
9ALPHA,11ALPHA-DIHYDROXY-15,15-DIFLUORO-16-PHENOXY-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID
(Z)-7-((1R,2R,3R,5S)-2-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoic acid
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-, (5Z)- | [Molecular Formula]
C22H28F2O5 | [MDL Number]
MFCD08062149 | [MOL File]
209860-88-8.mol | [Molecular Weight]
410.45 |
| Chemical Properties | Back Directory | [Boiling point ]
575.9±50.0 °C(Predicted) | [density ]
1.271±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DSMO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 3 mg/ml | [form ]
Oil | [pka]
4.76±0.10(Predicted) | [color ]
Colorless to light yellow | [Optical Rotation]
[α]/D 17 to 22°, c =1.0 in methanol | [InChIKey]
KIQXRQVVYTYYAZ-VKVYFNERSA-N | [SMILES]
C(O)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/C(F)(F)COC1=CC=CC=C1 |
| Hazard Information | Back Directory | [Uses]
Tafluprost Acid is a derivative of Tafluprost (T004820), a novel prostanoid used in the treatment of glaucoma and is the first prostanoid to be released in a preservative free-formula. | [Biological Activity]
Taflupost acid is the active metabolite of Tafluprosta prostaglandin F2α agonist th at lowers intraocular pressure and is used in the treatment of glaucoma. Taflupost acid has high affinity and selectivity for the prostaglandin PGF2α (FP) receptor with a Ki of 0.4 nM. | [IC 50]
Human FP Receptor: 0.4 nM (Ki); Human FP Receptor: 0.53 nM (EC50); EP3: 67 nM (IC50) | [storage]
Store at -20°C |
|
|