| Identification | Back Directory | [Name]
PAT-1251 | [CAS]
2098884-53-6 | [Synonyms]
PAT-1251
PAT-1251 Hydrochloride
PAT1251 Hydrochloride,PAT 1251 Hydrochloride | [Molecular Formula]
C18H18ClF4N3O3 | [MDL Number]
MFCD31715446 | [MOL File]
2098884-53-6.mol | [Molecular Weight]
435.8 |
| Hazard Information | Back Directory | [Uses]
PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively). PAT-1251 Hydrochloride is used in the research of fibrotic diseases. | [storage]
Store at -20°C | [References]
[1] Rowbottom MW, et al. Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2). J Med Chem. 2017 May 25;60(10):4403-4423. DOI:10.1021/acs.jmedchem.7b00345 |
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