| Identification | Back Directory | [Name]
Sulfamide, N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]-, hydrochloride (1:1) | [CAS]
2099681-71-5 | [Synonyms]
AT-121 hydrochloride
Sulfamide, N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]-, hydrochloride (1:1) | [Molecular Formula]
C24H39ClN4O3S | [MOL File]
2099681-71-5.mol | [Molecular Weight]
499.11 |
| Hazard Information | Back Directory | [Description]
AT-121 hydrochloride is a bifunctional nociception and mu opioid receptor agonist. It is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects. | [Uses]
AT-121 hydrochloride is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 hydrochloride is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects[1]. | [in vivo]
AT-121 hydrochloride (0.003-0.03 mg/kg; s.c.) produces potent antinociceptive effect[1]. | Animal Model: | Adult male and female rhesus monkeys[1] | | Dosage: | 0.003-0.03 mg/kg | | Administration: | Subcutaneous | | Result: | Produced antinociceptive effects against an acute noxious stimulus, 50 °C water, in a dose-dependent.
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| [IC 50]
μ Opioid Receptor/MOR | [References]
[1] Ding H, et al. A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates. Sci Transl Med. 2018;10(456):eaar3483. DOI:10.1126/scitranslmed.aar3483 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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