| Identification | Back Directory | [Name]
Ald-CH2-PEG4-CH2CO2tBu | [CAS]
2100306-54-3 | [Synonyms]
Ald-CH2-PEG3-CH2-Boc
Ald-CH2-PEG4-CH2CO2tBu | [Molecular Formula]
C14H26O7 | [MDL Number]
MFCD30828690 | [MOL File]
2100306-54-3.mol | [Molecular Weight]
306.35 |
| Hazard Information | Back Directory | [Description]
Ald-CH2-PEG4-CH2CO2tBu is a PEG linker with aldehyde and t-butyl moieties. Aldehyde is reactive to hydrazide and aminooxy groups which are commonly used in biomolecular probes for labeling and crosslinking carbonyls (oxidized carbohydrates). The t-butyl group can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of the compound. | [Uses]
Ald-CH2-PEG3-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of SGK3 kinase PROTAC degrader[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034. DOI:10.1021/acschembio.9b00505 |
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