| Identification | Back Directory | [Name]
t-Boc-Aminooxy-PEG4-azide | [CAS]
2100306-64-5 | [Synonyms]
Boc-NH-O-PEG5-azide
Boc-Aminooxy-PEG4-azide
t-Boc-Aminooxy-PEG4-azide | [Molecular Formula]
C15H30N4O7 | [MDL Number]
MFCD30723203 | [MOL File]
2100306-64-5.mol | [Molecular Weight]
378.421 |
| Hazard Information | Back Directory | [Description]
t-Boc-Aminooxy-PEG4-azide is a click chemistry reagent with a t-Boc-aminooxy group. The azide group is reactive with alkyne, such as BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The protected aminooxy can be deprotected under mild acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Boc-Aminooxy-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-Aminooxy-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651 |
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