| Identification | Back Directory | [Name]
t-Boc-Aminooxy-PEG1-azide | [CAS]
2100306-67-8 | [Synonyms]
Boc-Aminooxy-PEG1-azide
t-Boc-Aminooxy-PEG1-azide | [Molecular Formula]
C9H18N4O4 | [MDL Number]
MFCD30723202 | [MOL File]
2100306-67-8.mol | [Molecular Weight]
246.27 |
| Hazard Information | Back Directory | [Description]
t-Boc-Aminooxy-PEG1-azide is a PEG linker containing an azide group and Boc-protected aminoxy (NHO) group. It can react with alkyne, BCN, DBCO via Click Chemistry. The Boc group can be deprotected under mild acidic conditions to free the amine. | [Uses]
Boc-Aminooxy-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-Aminooxy-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651 |
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