| Identification | Back Directory | [Name]
NH-bis(PEG1-azide) | [CAS]
2100306-81-6 | [Synonyms]
NH-bis(PEG1-azide)
NH-bis(C2-PEG1-azide) | [Molecular Formula]
C8H17N7O2 | [MDL Number]
MFCD30730376 | [MOL File]
2100306-81-6.mol | [Molecular Weight]
243.27 |
| Chemical Properties | Back Directory | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C8H17N7O2/c9-14-12-3-7-16-5-1-11-2-6-17-8-4-13-15-10/h11H,1-8H2 | [InChIKey]
FXMWPZQWEUFICE-UHFFFAOYSA-N | [SMILES]
N(CCOCCN=[N+]=[N-])CCOCCN=[N+]=[N-] |
| Hazard Information | Back Directory | [Description]
NH-bis(PEG1-azide) is a PEG linker containing an amino group with two azide groups. The amino group is reactive with carboxylic acids, activated NHS esters. The azide groups enable PEGylation via Click Chemistry. | [Uses]
NH-bis(C2-PEG1-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH-bis(C2-PEG1-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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