| Identification | Back Directory | [Name]
3H-1-Thia-3,5,8-triazaacenaphthylene-2-carboxamide, 4,5-dihydro-5-[4-methyl-6-(2-methylpropyl)-3-pyridinyl]-4-oxo-N-[(1R,2S)-2-[(1-oxo-2-propen-1-yl)amino]cyclopentyl]- | [CAS]
2101524-34-7 | [Synonyms]
JNJ-64264681
3H-1-Thia-3,5,8-triazaacenaphthylene-2-carboxamide, 4,5-dihydro-5-[4-methyl-6-(2-methylpropyl)-3-pyridinyl]-4-oxo-N-[(1R,2S)-2-[(1-oxo-2-propen-1-yl)amino]cyclopentyl]- | [Molecular Formula]
C27H30N6O3S | [MOL File]
2101524-34-7.mol | [Molecular Weight]
518.63 |
| Chemical Properties | Back Directory | [Boiling point ]
843.6±65.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.60±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
JNJ-64264681 is a potent, orally active, selective and irreversible covalent BTK inhibitor. JNJ-64264681 exhibits good pharmacokinetic characteristics and can be used for cancer and autoimmune diseases research[1]. | [References]
[1] Mark S Tichenor, et al. Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. J Med Chem. 2022 Nov 10;65(21):14326-14336. DOI:10.1021/acs.jmedchem.2c01026 |
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