| Identification | Back Directory | [Name]
Squarunkin A | [CAS]
2101958-02-3 | [Synonyms]
Squarunkin A
1-Piperidinecarboxylic acid, 4-[[3,4-dioxo-2-[[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]amino]-1-cyclobuten-1-yl]amino]-, ethyl ester | [Molecular Formula]
C25H32F3N5O4 | [MDL Number]
MFCD32066931 | [MOL File]
2101958-02-3.mol | [Molecular Weight]
523.55 |
| Chemical Properties | Back Directory | [Boiling point ]
629.1±65.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
7.22±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A-myristoylated Src N-terminal peptide interaction (IC50=10 nM). Squarunkin A interferes with the activation of Src kinase in cells[1]. | [References]
[1] Tom Mejuch, et al. Small-Molecule Inhibition of the UNC119-Cargo Interaction. Angew Chem Int Ed Engl. 2017 May 22;56(22):6181-6186. DOI:10.1002/anie.201701905 |
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