| Identification | Back Directory | [Name]
Androst-4-en-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1-propyn-1-yl)-, (11β,17β)- | [CAS]
2102494-14-2 | [Synonyms]
OP-3633
Androst-4-en-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1-propyn-1-yl)-, (11β,17β)- | [Molecular Formula]
C30H39NO2 | [MDL Number]
MFCD32197211 | [MOL File]
2102494-14-2.mol | [Molecular Weight]
445.65 |
| Chemical Properties | Back Directory | [Boiling point ]
604.2±55.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
13.00±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism[1]. | [storage]
Store at -20°C | [References]
[1] Du X, et al. Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633). J Med Chem. 2019 Jul 25;62(14):6751-6764. DOI:10.1021/acs.jmedchem.9b00711 |
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