| Identification | Back Directory | [Name]
Brr2 Inhibitor C9 | [CAS]
2104030-82-0 | [Synonyms]
Brr2 Inhibitor C9
Pyrido[4,3-d]pyrimidine-2,7(1H,3H)-dione, 4,6-dihydro-6-(phenylmethyl)-3-[3-(5-thiazolylmethoxy)phenyl]- | [Molecular Formula]
C24H20N4O3S | [MOL File]
2104030-82-0.mol | [Molecular Weight]
444.51 |
| Chemical Properties | Back Directory | [Boiling point ]
777.4±60.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO : 50 mg/mL (112.48 mM; Need ultrasonic) | [form ]
Solid | [pka]
11.84±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Brr2-IN-3 is a potent and selective Brr2 helicase allosteric Inhibitor. Brr2-IN-3 inhibits helicase activity in dose-dependent manner with an IC50 value of 1.3 μM[1]. | [References]
[1] Iwatani-Yoshihara M, et al. Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J Med Chem. 2017;60(13):5759-5771. DOI:10.1021/acs.jmedchem.7b00461 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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