| Hazard Information | Back Directory | [Uses]
(-)-5-HT2C agonist-3 (compound (–)-19) is a 5-HT2C selective agonist with Gq signaling preference, with EC50 values ??for 5-HT2 receptors of 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM. (-)-5-HT2C agonist-3 can be used in antipsychotic research[1]. | [IC 50]
5-HT2A Receptor: 72 nM (IC50); 5-HT2C Receptor: 103 nM (IC50); 5-HT2B Receptor: 570 nM (IC50) | [References]
[1] Guiping Zhang, et al. "Discovery of N-substituted (2-phenylcyclopropyl) methylamines as functionally selective serotonin 2C receptor agonists for potential use as antipsychotic medications." Journal of medicinal chemistry 60.14 (2017): 6273-6288. |
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