| Identification | Back Directory | [Name]
N-(m-PEG9)-N'-(PEG5-acid)-Cy5 | [CAS]
2107273-26-5 | [Synonyms]
N-(m-PEG9)-N'-(PEG5-acid)-Cy5 | [Molecular Formula]
C57H89ClN2O16 | [MDL Number]
MFCD29079416 | [MOL File]
2107273-26-5.mol | [Molecular Weight]
1093.79 |
| Hazard Information | Back Directory | [Description]
N-(m-PEG9)-N'-(PEG5-acid)-Cy5 is a near infrared (NIR) fluorescent Cy 5 labeled PEG linker containing free terminal carboxyl acid. Terminal carboxylic acid can react with primary amine groups in the presence of of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydophilic PEG spacer increases solubility in aqueous media. Cy5 labeled PEG linker can be easily traced from its blue color and strong fluorescence. | [Uses]
N-(m-PEG9)-N'-(PEG5-acid)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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