| Identification | Back Directory | [Name]
4-(4-OXO-4H-BENZO[H]CHROMEN-2-YL)-PYRIDINIUM BISULFATE | [CAS]
2110-25-0 | [Synonyms]
UCCF029
UCCF-029
UCCF 029
UC(CF)029
UC(CF)-029
UC(CF) 029
4H-Naphtho[1,2-b]pyran-4-one, 2-(4-pyridinyl)-
4-(4-OXO-4H-BENZO[H]CHROMEN-2-YL)-PYRIDINIUM BISULFATE | [Molecular Formula]
C18H11NO2 | [MDL Number]
MFCD06753112 | [MOL File]
2110-25-0.mol | [Molecular Weight]
273.29 |
| Hazard Information | Back Directory | [Description]
UCCF-029 is a novel cystic fibrosis transmembrane conductance regulator (CFTR) activator. | [Uses]
UCCF-029 Free base is a potent activator of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. UCCF-029 Free base exhibits enhanced activity through benzannulation of the flavone A-ring at the 7,8-position. UCCF-029 Free base serves as a structural guide for the development of more effective flavonoid analogues. UCCF-029 Free base demonstrates improved potency compared to apigenin in activating wild-type CFTR. UCCF-029 Free base also exhibits potential for activating the mutant CFTR (G551D-CFTR) though not as robustly as apigenin. | [Definition]
ChEBI: 2-pyridin-4-yl-4-benzo[h][1]benzopyranone is an organic heterotricyclic compound and an organooxygen compound. | [References]
[1] Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain |
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| Company Name: |
Matrix Scientific
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| Tel: |
803 788-9494 All other calls |
| Website: |
www.matrixscientific.com |
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