| Identification | Back Directory | [Name]
Boc-Gly-PEG3-endo-BCN | [CAS]
2110444-63-6 | [Synonyms]
Boc-Gly-PEG3-endo-BCN
9,12,15-Trioxa-2,5,19-triazaeicosanedioic acid, 4-oxo-, 20-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 1-(1,1-dimethylethyl) ester | [Molecular Formula]
C28H47N3O8 | [MDL Number]
MFCD31692209 | [MOL File]
2110444-63-6.mol | [Molecular Weight]
553.69 |
| Hazard Information | Back Directory | [Description]
Boc-Gly-PEG3-endo-BCN is a Boc protected cick chemistry reagent with a BCN group. The hydrophilic PEG spacer increases solubility in aqueous media. The BCN group is reactive with azide-tagged molecules. | [Uses]
Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-gly-PEG3-endo-BCN is also a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Boc-gly-PEG3-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether; Cleavable Linker | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
[2] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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