| Identification | Back Directory | [Name]
N-DBCO-N-bis(PEG2-acid) | [CAS]
2110449-00-6 | [Synonyms]
N-DBCO-N-bis(PEG2-acid)
N-DBCO-N-bis(PEG2-C2-acid) | [Molecular Formula]
C33H40N2O10 | [MDL Number]
MFCD29912780 | [MOL File]
2110449-00-6.mol | [Molecular Weight]
624.69 |
| Chemical Properties | Back Directory | [Boiling point ]
891.4±65.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [form ]
Liquid | [pka]
3.97±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
N-DBCO-N-bis(PEG2-acid) is a branched click chemistry linker containing a DBCO and two PEG2-acid chains attached to a central nitrogen group. The DBCO group participates in copper-free Click Chemistry reactions with azide. Carboxylic acid (CO2H) allows for reactions with primary amine groups using activators such as EDC or HATU to form a stable bond. | [Uses]
N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-DBCO-N-bis(PEG2-C2-acid) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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