| Identification | Back Directory | [Name]
Glutaminyl Cyclase Inhibitor 1 | [CAS]
2110449-60-8 | [Synonyms]
Glutaminyl Cyclase Inhibitor 1
1H-Imidazole-1-propanamine, N-(3-fluoro-3',4'-dimethoxy[1,1'-biphenyl]-2-yl)-4-methyl- | [Molecular Formula]
C21H24FN3O2 | [MDL Number]
MFCD31657434 | [MOL File]
2110449-60-8.mol | [Molecular Weight]
369.43 |
| Chemical Properties | Back Directory | [Boiling point ]
568.3±50.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 83.33 mg/mL (225.56 mM) | [form ]
Solid | [pka]
7.49±0.61(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor with an IC50 of 0.5 μM. | [Biological Activity]
Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor with IC50 of 0.5 μM. | [in vitro]
Glutaminyl Cyclase Inhibitor 1 is compound 23. | [target]
IC50: 0.5 μM (Glutaminyl cyclase) | [References]
[1] Li M, et al. Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer's Disease. J Med Chem. 2017 Aug 10;60(15):6664-6677. DOI:10.1021/acs.jmedchem.7b00648 |
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