| Identification | Back Directory | [Name]
N-(Azido-PEG3)-N-Boc-PEG4-NHS ester | [CAS]
2112731-96-9 | [Synonyms]
HUN 31969
N-(Azido-PEG3)-N-Boc-PEG4-NHS ester
N-(Azido-PEG4)-N-Boc-PEG4-NHS ester | [Molecular Formula]
C28H49N5O13 | [MDL Number]
MFCD30723220 | [MOL File]
2112731-96-9.mol | [Molecular Weight]
663.714 |
| Hazard Information | Back Directory | [Description]
N-(Azido-PEG3)-N-Boc-PEG4-NHS ester is a branched PEGylation reagent with a terminal azide group (N3), a Boc protected amine (NH2), and a terminal NHS ester.The azide group enables PEGylation via Click Chemistry. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The protected amine can be deprotected under acidic conditions. | [Uses]
N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is a PEG-based PROTAC linker with a terminal azide group. N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is used in the synthesis of PROTACs[1] N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] Kanazaki K, et al. Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. J Control Release. 2016 Mar 28;226:115-23. DOI:10.1016/j.jconrel.2016.02.017 |
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