| Identification | Back Directory | [Name]
N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) | [CAS]
2112732-01-9 | [Synonyms]
N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester)
4,11,14,17,20-Pentaoxa-7-azatricos-22-ynoic acid, 7-[2-(3-methoxy-3-oxopropoxy)ethyl]-8-oxo-, methyl ester | [Molecular Formula]
C24H41NO11 | [MDL Number]
MFCD30723219 | [MOL File]
2112732-01-9.mol | [Molecular Weight]
519.58 |
| Chemical Properties | Back Directory | [Boiling point ]
589.3±50.0 °C(Predicted) | [density ]
1.134±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
-0.92±0.70(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a crosslinker that can react with azide compounds or biomolecules via copper catalyzed Click Chemistry to form a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions. | [Uses]
N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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