| Identification | Back Directory | [Name]
N-(Hydroxy-PEG3)-N-bis(PEG4-t-butyl ester) | [CAS]
2112734-70-8 | [Synonyms]
HUN 34708
N-(Hydroxy-PEG3)-N-bis(PEG4-Boc)
N-(Hydroxy-PEG3)-N-bis(PEG4-t-butyl ester)
4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 16-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]-, 1,31-bis(1,1-dimethylethyl) ester | [Molecular Formula]
C38H75NO16 | [MDL Number]
MFCD30730366 | [MOL File]
2112734-70-8.mol | [Molecular Weight]
802 |
| Hazard Information | Back Directory | [Description]
N-(Hydroxy-PEG3)-N-bis(PEG4-t-butyl ester) is a branched PEG linker with a terminal hydroxy group and two t-butyl esters. The hydroxy group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl groups can be deprotected under mild acidic conditions. | [Uses]
N-(Hydroxy-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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