| Identification | Back Directory | [Name]
N-(Aminooxy-PEG3)-N-bis(PEG4-t-butyl ester) | [CAS]
2112737-19-4 | [Synonyms]
IUN 37194
N-(Aminooxy-PEG3)-N-bis(PEG4-Boc)
N-(Aminooxy-PEG3)-N-bis(PEG4-t-butyl ester)
4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 16-[2-[2-[2-[2-(aminooxy)ethoxy]ethoxy]ethoxy]ethyl]-, 1,31-bis(1,1-dimethylethyl) ester | [Molecular Formula]
C38H76N2O16 | [MDL Number]
MFCD30730364 | [MOL File]
2112737-19-4.mol | [Molecular Weight]
817.01 |
| Chemical Properties | Back Directory | [Boiling point ]
763.1±60.0 °C(Predicted) | [density ]
1.089±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
6.91±0.50(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
N-(Aminooxy-PEG3)-N-bis(PEG4-t-butyl ester) is a branched aminooxy linker. It can react with aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The t-butyl ester group can be hydrolyzed under acidic conditions. The hydrophilic PEG linkers increase the water solubility of the compound. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
N-(Aminooxy-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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