| Identification | Back Directory | [Name]
Interphotoreceptor Retinoid Binding Protein Fragment IRBP | [CAS]
211426-18-5 | [Synonyms]
Interphotoreceptor Retinoid Binding Protein Fragment IRBP
L-Aspartic acid, L-serylglycyl-L-isoleucyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-isoleucyl-L-seryl-L-tyrosyl-L-leucyl-L-histidyl-L-prolylglycyl-L-asparaginyl-L-threonyl-L-isoleucyl-L-leucyl-L-histidyl-L-valyl- | [Molecular Formula]
C103H157N25O29 | [MDL Number]
MFCD32068015 | [MOL File]
211426-18-5.mol | [Molecular Weight]
2209.5 |
| Chemical Properties | Back Directory | [Boiling point ]
2290.5±65.0 °C(Predicted) | [density ]
1.315±0.06 g/cm3(Predicted) | [Sequence]
Ser-Gly-Ile-Pro-Tyr-Ile-Ile-Ser-Tyr-Leu-His-Pro-Gly-Asn-Thr-Ile-Leu-His-Val-Asp |
| Hazard Information | Back Directory | [Uses]
Interphotoreceptor Retinoid Binding Protein Fragment (IRBP), a 20-residue peptide and a major pathogenic epitope, is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP 161–180), which can induce posterior uveitis (EAU)[1]. | [References]
[1] Tang J, et al. Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signatureand is driven by unique effector mechanisms: initial encounter with autoantigen defines diseasephenotype. J Immunol. 2007 May 1;178(9):5578-87. DOI:10.4049/jimmunol.178.9.5578
[2] Cortes LM, et al. Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinalautoimmunity by inducing type 2 and regulatory T cells. J Leukoc Biol. 2008 Aug;84(2):577-85. DOI:10.1189/jlb.0308189
[3] Yang H, et al. Activation of liver X receptor alleviates ocular inflammation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2014 Apr 28;55(4):2795-804. DOI:10.1167/iovs.13-13323 |
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