| Chemical Properties | Back Directory | [Boiling point ]
669.7±55.0 °C(Predicted) | [density ]
1.299±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 10mg/mL, clear | [form ]
powder | [pka]
13.88±0.40(Predicted) | [color ]
white to beige | [InChIKey]
RBMHKFVYRIRMOG-GOTSBHOMSA-N | [SMILES]
CC1=CC(CN([C@@H]2[C@@H](O)COCC2)C3=O)=C3C=C1CC4=CC=C(C5=COC=N5)C=C4 |
| Hazard Information | Back Directory | [Uses]
PF-06827443 is a potent, low-clearance, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with minimal agonist activity. PF-06827443 induce cholinergic AEs and convulsion[1]. | [Biochem/physiol Actions]
PF-06827443 is a otent, low clearance, orally bioavailable, and CNS penetrant muscarinic M1-selectivepositive allosteric modulator (PAM) with minimal agonist activity. | [References]
[1] Jennifer E Davoren, et, al. Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity. J Med Chem. 2017, 60, 15. DOI:10.1021/acs.jmedchem.7b00597 |
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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