| Identification | Back Directory | [Name]
3-Isoquinolinecarboxylic acid, 6-[(4-carboxyphenyl)methyl]decahydro-, (3S,4aR,6S,8aR)- | [CAS]
211566-75-5 | [Synonyms]
LY382884
LY-382884
LY 382884
3-Isoquinolinecarboxylic acid, 6-[(4-carboxyphenyl)methyl]decahydro-, (3S,4aR,6S,8aR)- | [Molecular Formula]
C18H23NO4 | [MDL Number]
MFCD09970605 | [MOL File]
211566-75-5.mol | [Molecular Weight]
317.38 |
| Hazard Information | Back Directory | [Description]
LY382884 is a GLU(K5) receptor antagonist. LY382884 selectively binds the GLU(K5) kainate receptor subunit (K(b)=0.6 microM) and has 30 microM or greater affinity for cloned human AMPA receptor subtypes. GluR5-mediated glutamate signaling regulates hypothalamo-pituitary-adrenocortical stress responses at the paraventricular nucleus and median eminence. | [Uses]
LY382884 is a selective antagonist for GluR5 kainate receptor. LY382884 prevents the induction of NMDA receptor independent long-term potentiation (LTP)[1]. | [Definition]
ChEBI: LY382884 is a member of benzoic acids. | [References]
[1] Bortolotto ZA, et al., Kainate receptors are involved in synaptic plasticity. Nature. 1999 Nov 18;402(6759):297-301. DOI:10.1038/46290 |
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