| Identification | Back Directory | [Name]
Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-7-hydroxy-3-(hydroxymethyl)-, (3S,7R,8aS)- | [CAS]
211868-63-2 | [Synonyms]
Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-7-hydroxy-3-(hydroxymethyl)-, (3S,7R,8aS)- | [Molecular Formula]
C8H12N2O4 | [MOL File]
211868-63-2.mol | [Molecular Weight]
200.19 |
| Hazard Information | Back Directory | [Description]
JBP485 is an inhibitor of renal transporters OAT1 and OAT3. JBP485 is an antihepatitis agent as a substrate for intestinal PEPT1. | [Uses]
JBP485 (cyclo-trans-4-L-hydroxyprolyl-L-serine) is a dipeptide with anti-hepatotoxic and wound healing properties. JBP485 can be used for research of various kinds of corneal epithelial diseases[1]. | [in vivo]
JBP485 (100 μM, topical application, 4 times per day) accelerates the corneal epithelial wound healing on rabbits (4 days for healing completely, compared with 5 days for control group)[1].
| [References]
[1] Nagata M, et al. JBP485 promotes corneal epithelial wound healing. Sci Rep. 2015 Oct 1;5:14776. DOI:10.1038/srep14776 |
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