| Identification | Back Directory | [Name]
5-Amino-6-chloro-3-pyridinecarboxylic acid methyl ester | [CAS]
211915-96-7 | [Synonyms]
Fampridine Impurity 231
5-AMino-6-chloro-nicotinic acid Methyl ester
Methyl 5-aMino-6-chloropyridine-3-carboxylate
Methyl 5-amino-6-chloro-3-pyridinecarboxylate
5-Amino-6-chloro-3-pyridinecarboxylic acid methyl ester
3-Pyridinecarboxylic acid, 5-aMino-6-chloro-, Methyl ester | [Molecular Formula]
C7H7ClN2O2 | [MDL Number]
MFCD02180841 | [MOL File]
211915-96-7.mol | [Molecular Weight]
186.6 |
| Chemical Properties | Back Directory | [Boiling point ]
328.2±37.0 °C(Predicted) | [density ]
1.384±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
0.20±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 5-amino-6-chloronicotinic acid methyl ester from 6-chloro-5-nitronicotinic acid: a suspension of methyl 6-chloro-5-nitronicotinic acid (1 eq.), iron powder (5.2 eq.) and NH4Cl (5.3 eq.) in methanol was heated and reacted for 2 hr at 75 °C. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad while hot and the filtrate was subsequently concentrated in vacuum to afford the target product methyl 5-amino-6-chloronicotinate in 56% yield. | [References]
[1] Patent: WO2010/71853, 2010, A1. Location in patent: Page/Page column 68
[2] Patent: WO2013/169704, 2013, A2. Location in patent: Paragraph 0290
[3] Patent: WO2015/95795, 2015, A1. Location in patent: Paragraph 0378 |
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