| Identification | Back Directory | [Name]
CHK1-IN-4 | [CAS]
2120398-41-4 | [Synonyms]
CHK1-IN-4
CHK-1-IN-4,CHK1 IN 4,CHK1IN4
2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-4-bromo-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]- | [Molecular Formula]
C18H18BrN7O2 | [MDL Number]
MFCD32215333 | [MOL File]
2120398-41-4.mol | [Molecular Weight]
444.29 |
| Hazard Information | Back Directory | [Uses]
CHK1-IN-4 (Compound 3) is a potent checkpoint kinase 1 (chk1) inhibitor, and potently inhibits chk1 phosphorylation in the tumor cells. CHK1-IN-4 has anti-tumor activity[1]. | [in vivo]
CHK1-IN-4 (Compound 3) (40 mg/kg, IV, twice a week) alone enhances anti-tumor growth activity of CPT1 in the tumor model[1]. | [IC 50]
Chk1 | [References]
[1] Xiong Cai, et al. 3,5-disubstituted pyrazoles useful as checkpoint kinase 1 (chk1) inhibitors, and their preparations and applications. WO2017132928A1. |
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