| Identification | Back Directory | [Name]
Benzamide, 5-chloro-N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy- | [CAS]
212135-62-1 | [Synonyms]
ZT-1a
Benzamide, 5-chloro-N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy- | [Molecular Formula]
C22H15Cl3N2O2 | [MOL File]
212135-62-1.mol | [Molecular Weight]
445.73 |
| Chemical Properties | Back Directory | [Boiling point ]
538.7±50.0 °C(Predicted) | [density ]
1.442±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 125 mg/mL (280.44 mM) | [form ]
Solid | [pka]
7?+-.0.43(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ZT-1a is a potent, non-ATP-competitive and selective SPAK inhibitor. ZT-1a inhibits SPAK activity with IC50s of 44.3, 35.0, 46.7 μM at ATP concentrations of 0.01, 0.1 and 1 mM, respectively[1]. | [in vivo]
ZT-1a (10-100 mg/kg) inhibits SPAK-dependent cation-Cl cotransporters (CCC) phosphorylation in vivo[1]. | Animal Model: | Naive mice[1] | | Dosage: | 10, 30, 50, and 100?mg/kg | | Administration: | Intraperitoneal (i.p.) administration | | Result: | Inhibited SPAK-dependent cation-Cl- cotransporters (CCC) phosphorylation in vivo. |
| [storage]
Store at -20°C | [References]
[1] Jinwei Zhang, et al. Modulation of Brain cation-Cl- Cotransport via the SPAK Kinase Inhibitor ZT-1a. Nat Commun. 2020 Jan 7;11(1):78. DOI:10.1038/s41467-019-13851-6 |
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| Company Name: |
G-CLONE
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| Tel: |
400-910-1997 15330005590 |
| Website: |
http://www.g-clone.com/ |
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