| Identification | Back Directory | [Name]
Vatalanib base | [CAS]
212141-54-3 | [Synonyms]
VataL
VATALANIB
PTK787 2HCl
Vatalanib 2HCL
VATALANIB BASE
PTK/ZK free base
PTK787 free base
Vatalanib (PTK787)
anib (PTK787) 2HCL
CGP-79787 free base
ZK-222584 free base)
Vatalanib (free base)
SORAFENIB BASE VATALANIB
Vatalanib free base (PTK787 free base
ZK 222584 (CPG-79787) 2HCL;PTK787 2HCL
Vatalanib (PTK787) Dihydrochloride Base
Pynasunate, ZK222584, CGP-79787, PTK 787
N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)- 1-Phthalazinamine
1-PhthalazinaMine, N-(4-chlorophenyl)-4-(4-pyridinylMethyl)-
(4-Chloro-phenyl)-(4-pyridin-4-ylmethyl-phthalazin-1-yl)-amine
PTK787 FREE BASE; PTK/ZK FREE BASE; CGP-79787 FREE BASE; ZK-222584 FREE BASE | [Molecular Formula]
C20H15ClN4 | [MDL Number]
MFCD08458963 | [MOL File]
212141-54-3.mol | [Molecular Weight]
346.81 |
| Chemical Properties | Back Directory | [Melting point ]
209-212° | [Boiling point ]
587.8±50.0 °C(Predicted) | [density ]
1.330±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [solubility ]
≥16.85 mg/mL in DMSO; ≥3.0125 mg/mL in EtOH with gentle warming and ultrasonic; ≥32.53 mg/mL in H2O with gentle warming and ultrasonic | [form ]
solid | [pka]
5.46±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
anti-viral | [Uses]
Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively. | [Definition]
ChEBI: A member of the class of phthalazines that is phthalazine in which the hydrogens at positions 1 and 4have been replaced by a p-chlorophenylamino group and a pyridin-4-ylmethyl group, respectively. It is a multi-targeted tyrosine kinase inhibit
r for all isoforms of VEGFR, PDGFR and c-Kit. | [in vivo]
Vatalanib induces dose-dependent inhibition of the angiogenic response to VEGF and PDGF in both a growth factor implant model and a tumor cell-driven angiogenesis model after once-daily oral dosing (25-100 mg/kg). In the same dose range, Vatalanib also inhibits the growth and metastasesof several human carcinomas in nude mice without significant effect on circulating blood cells or bone marrow leukocytes[1]. | [IC 50]
VEGFR2: 37 nM (IC50) | [storage]
Store at -20°C |
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