| Identification | Back Directory | [Name]
6-FLUORO-3,4-PYRIDINEDIAMINE | [CAS]
212268-13-8 | [Synonyms]
5-Fluoro-2,3-diaminopyridine
5-fluoro-2,3-pyridinediaMine
6-FLUORO-3,4-PYRIDINEDIAMINE
2,3-PyridinediaMine,5-fluoro-
2,3-Pyridinediamine,5-fluoro-(9CI)
6-FLUORO-3,4-PYRIDINEDIAMINE ISO 9001：2015 REACH | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C5H6FN3 | [MDL Number]
MFCD08062986 | [MOL File]
212268-13-8.mol | [Molecular Weight]
127.12 |
| Chemical Properties | Back Directory | [Boiling point ]
303.9±37.0 °C(Predicted) | [density ]
1.390±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
solid | [pka]
4.50±0.49(Predicted) | [color ]
Faint brown to light brown |
| Hazard Information | Back Directory | [Synthesis]
Example 2.5 Synthesis of 2,3-diamino-5-fluoropyridine: 2-amino-5-fluoro-3-nitropyridine (0.42 g, 2.3 mmol) and iron powder (1.6 g, 28 mmol) were dissolved in ethanol (10 mL), followed by addition of water (0.5 mL, 28 mmol) and hydrochloric acid (27 μL, 0.32 mmol). The reaction mixture was heated and refluxed for 1 hour. After that, iron powder (0.2 g, 3.6 mmol) was added additionally and reflux was continued for 30 min. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to give 0.3 g of crude product (100% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 3.55 (broad peak, 2H), 4.1 (broad peak, 2H), 6.7 (double peak, 1H), 7.5 (single peak, 1H). | [References]
[1] Patent: US6265415, 2001, B1 |
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