| Identification | Back Directory | [Name]
VU6007496 | [CAS]
2127101-85-1 | [Synonyms]
VU6007496
1H-Pyrrolo[3,2-b]pyridine-5-carboxamide, 1-methyl-7-[[4-(1-methyl-1H-pyrazol-3-yl)phenyl]methyl]-N-(tetrahydro-2H-pyran-4-yl)- | [Molecular Formula]
C25H27N5O2 | [MOL File]
2127101-85-1.mol | [Molecular Weight]
429.52 |
| Chemical Properties | Back Directory | [Boiling point ]
686.427±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.302±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
12.131±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
VU6007496 is a highly selective and CNS penetrant M1 positive allosteric modulator (PAM). VU6007496 shows excellent pharmacokinetics (PK)[1]. | [References]
[1] Engers JL, et al. Discovery of VU6007496: Challenges in the Development of an M1 Positive Allosteric Modulator Backup Candidate. ACS Chem Neurosci. 2024 Aug 28. DOI:10.1021/acschemneuro.4c00508 |
|
|