2127875-65-2

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2127875-65-2 Structure

Identification	Back Directory
[Name] S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate
[CAS] 2127875-65-2
[Synonyms] S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate
[Molecular Formula] C5H12O3S2
[MDL Number] MFCD32701927
[MOL File] 2127875-65-2.mol
[Molecular Weight] 184.27

Chemical Properties	Back Directory
[Boiling point ] 348.6±25.0 °C(Predicted)
[density ] 1.283±0.06 g/cm3(Predicted)
[form ] Oil
[pka] 14.03±0.10(Predicted)
[color ] Colorless to light yellow

Hazard Information	Back Directory
[Uses] S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) and refers to the Alkyl-Chain composition. S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is the linker portions of the molecules employed for mAb attachment purposes[1].
[IC 50] Disulfide Cleavable Linker; Cleavable Linker
[References] [1] Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31. DOI:10.1002/cmdc.201900497

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