| Identification | Back Directory | [Name]
Boc-aminooxy-ethyl-SS-propanol | [CAS]
2128735-21-5 | [Synonyms]
Boc-aminooxy-ethyl-SS-propanol | [Molecular Formula]
C9H19NO4S2 | [MDL Number]
MFCD31536770 | [MOL File]
2128735-21-5.mol | [Molecular Weight]
269.38 |
| Hazard Information | Back Directory | [Description]
Boc-aminooxy-ethyl-SS-propanol is a cleavable linker contains a Boc protected aminooxy group. The protected aminooxy can be deprotected under mild acidic conditions and can then be reacted with an aldehyde or ketone group to form a stable oxime linkage. The disulfide bond can be cleaved by reduction. | [Uses]
Boc-aminooxy-ethyl-SS-propanol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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