| Identification | Back Directory | [Name]
N-Mal-N-bis(PEG4-amine) TFA salt | [CAS]
2128735-22-6 | [Synonyms]
N-Mal-N-bis(PEG4-amine)
N-Mal-N-bis(PEG4-amine) TFA salt
1H-Pyrrole-1-propanamide, N,N-bis(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-2,5-dihydro-2,5-dioxo- | [Molecular Formula]
C27H50N4O11 | [MDL Number]
MFCD31692216 | [MOL File]
2128735-22-6.mol | [Molecular Weight]
606.71 |
| Hazard Information | Back Directory | [Description]
N-Mal-N-bis(PEG4-amine) TFA salt is a branched PEG linker with a terminal maleimide group and two terminal amino groups. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. | [Uses]
N-Mal-N-bis(PEG4-amine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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