| Identification | Back Directory | [Name]
Mal-NH-ethyl-SS-propionic acid | [CAS]
2128735-24-8 | [Synonyms]
Mal-NH-ethyl-SS-propionic acid | [Molecular Formula]
C12H16N2O5S2 | [MDL Number]
MFCD31536759 | [MOL File]
2128735-24-8.mol | [Molecular Weight]
332.4 |
| Chemical Properties | Back Directory | [Boiling point ]
638.5±50.0 °C(Predicted) | [density ]
1.437±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DMF | [form ]
Solid | [pka]
4.25±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Mal-NH-ethyl-SS-propionic acid is a cleavabe, Maleimide linker. The maleimide group will react with thiol groups to form a covalent bond, enabling the connection of biomolecule to a thiol. Terminal carboxylic acids can react with primary amine groups using activators such as EDC and HATU to from stable amide bonds. | [Uses]
Mal-NH-ethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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