| Identification | Back Directory | [Name]
1,2-BENZENEDIAMINE, 4-IODO- | [CAS]
21304-38-1 | [Synonyms]
2-Amino-4-iodoaniline
2-Amino-5-iodoaniline
4-Iodo-1,2-benzenediamine
1,2-Diamino-4-iodobenzene
4-Iodo-o-phenylenediamine
2-Amino-4-iodophenylamine
4-Iodo-1,2-diaminobenzene
4-iodo-1,2-phenylenediaMine
1,2-BENZENEDIAMINE, 4-IODO-
4-Iodo-o-phenylenediamine,95%
4-Iodobenzene-1,2-diamine 97%
4-Iodo-1,2-phenylenediamine97%
4-IODO-1,2-PHENYLENEDIAMINE 97%
1,2-DiaMino-4-iodobenzene[3,4-DiaMinoiodobenzene]
1,2-Diamino-4-iodobenzene, 4-Iodophenylene-1,2-diamine | [Molecular Formula]
C6H7IN2 | [MDL Number]
MFCD08669466 | [MOL File]
21304-38-1.mol | [Molecular Weight]
234.038 |
| Chemical Properties | Back Directory | [Melting point ]
73-77℃ | [Boiling point ]
339.0±32.0 °C(Predicted) | [density ]
2.016 | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [form ]
Solid | [pka]
3.37±0.10(Predicted) | [Appearance]
Light brown to brown Solid | [Water Solubility ]
Slightly soluble in water. | [Sensitive ]
Light Sensitive | [InChI]
InChI=1S/C6H7IN2/c7-4-1-2-5(8)6(9)3-4/h1-3H,8-9H2 | [InChIKey]
FUOSRKZBOIVBOS-UHFFFAOYSA-N | [SMILES]
C1(N)=CC=C(I)C=C1N | [CAS DataBase Reference]
21304-38-1 |
| Hazard Information | Back Directory | [Uses]
It is employed in the synthesis of N-(Benzimidazol-2-ylmethyl)iminodiacetic acids. | [Synthesis]
Using 4-iodo-2-nitroaniline as starting material, the reduction reaction was carried out by adding 5 equivalents of tin dichloride dihydrate to an ethanol solution and reacting at 75°C for 2 hours. Upon completion of the reaction, 4-iodo-1,2-benzenediamine was obtained in 92% yield and the product was a light red solid. | [References]
[1] Patent: WO2010/43711, 2010, A1. Location in patent: Page/Page column 56
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6714 - 6723
[3] Patent: US2012/46307, 2012, A1. Location in patent: Page/Page column 27
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7241 - 7257
[5] Patent: JP2016/79108, 2016, A. Location in patent: Paragraph 0051 |
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