| Identification | Back Directory | [Name]
AN11251 | [CAS]
2130750-59-1 | [Synonyms]
AN11251
Acetic acid, 2-[(7-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)oxy]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester | [Molecular Formula]
C29H38BFO7 | [MDL Number]
MFCD31813806 | [MOL File]
2130750-59-1.mol | [Molecular Weight]
528.42 |
| Hazard Information | Back Directory | [Description]
AN11251 is a potenet Anti-Wolbachia Agent with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis (EC50 = 1.5nM for LDW1 cell lines and 15 nM for C6/36 cell lines). AN11251 showed in vitro anti-Wolbachia activity and physicochemical and pharmacokinetic properties providing high exposure in plasma. | [Uses]
AN11251 is a potent and oral active anti-Wolbachia agent with potential for treatment of onchocerciasis and lymphatic filariasis, with EC50 values of 1.5 nM in LDW1 cell lines and 15 nM in C6/36 cell lines[1]. | [in vivo]
AN11251 (25 mg/kg, PO, BID for 7 or 14 days) reduces the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively[1]. | Animal Model: | CB.17 SCID mice inoculated with 50 L3-stage B. malayi larvae[1]. | | Dosage: | 25 mg/kg. | | Administration: | Orally, BID for 7 or 14 days. | | Result: | Reduced the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively. |
| [References]
[1] Jacobs RT, et al. Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis. J Med Chem. 2019 Mar 14;62(5):2521-2540. DOI:10.1021/acs.jmedchem.8b01854 |
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