| Identification | Back Directory | [Name]
1H-Pyrazole-4-carboxamide, 5-methyl-1-phenyl-N-2-quinolinyl- | [CAS]
2131223-92-0 | [Synonyms]
YW2036
1H-Pyrazole-4-carboxamide, 5-methyl-1-phenyl-N-2-quinolinyl- | [Molecular Formula]
C20H16N4O | [MOL File]
2131223-92-0.mol | [Molecular Weight]
328.37 |
| Chemical Properties | Back Directory | [Boiling point ]
474.9±35.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.76±0.43(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
YW2036 (compound 2a) is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC50 value of 637 nM. YW2036 can be used in research of cancer[1]. | [References]
[1] Yang W, et, al. Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation. J Med Chem. 2019 Dec 26;62(24):11151-11164. DOI:10.1021/acs.jmedchem.9b01252 |
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