| Identification | Back Directory | [Name]
(±)5,6-DHET lactone | [CAS]
213126-92-2 | [Synonyms]
(±)5,6-DHET lactone
(±)5(6)-DiHET lactone
(6S)-6-[(1R,3Z,6Z,9Z)-1-hydroxypentadeca-3,6,9-trienyl]oxan-2-one
2H-Pyran-2-one, tetrahydro-6-[(3Z,6Z,9Z)-1-hydroxy-3,6,9-pentadecatrien-1-yl]- | [Molecular Formula]
C20H32O3 | [MOL File]
213126-92-2.mol | [Molecular Weight]
320.47 |
| Chemical Properties | Back Directory | [Boiling point ]
483.4±40.0 °C(Predicted) | [density ]
0.993±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml | [pka]
13.89±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
5,6-DiHET lactone ((±)5,6-DiHETrE lactone) is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.1 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME. | [Definition]
ChEBI: 5,6-Dihydroxy-8Z,11Z,14Z-eicosatrienoic acid, 1,5-lactone is a long-chain fatty alcohol. | [storage]
Store at -20°C | [References]
[1] Oltman, et al. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. Circ. Res. 83(9), 932-939 (1998). |
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